Cytochrome P450 Inhibitors And Inducers Table

This is a list of cytochrome p450 modulators or inhibitors and inducers of cytochrome p450 enzymes.

Cytochrome p450 inhibitors and inducers table.

A moderate inhibitor is one that causes a 2 fold increase in the plasma auc values or 50 80 decrease in clearance. Substrates inducers and inhibitors of cytochrome p450 preventing drug drug interactions in psychiatry. Paroxetine a cytochrome p450 2d6 inhibitor. Drug interactions are referred to as either inhibitors or inducers table 1 10.

The table contains lists of drugs in columns under the designation of specific cytochrome p450 isoforms. This table is designed as a hypothesis testing teaching and reference tool for physicians and researchers interested in drug interactions that are the result of competition for or effects on the human cytochrome p450 system. Drug development and drug interactions. Abbreviated clinically relevant table inhibitors a strong inhibitor is one that causes a 5 fold increase in the plasma auc values or more than 80 decrease in clearance.

Table of substrates inhibitors and inducers drug development and drug interactions. Cytochrome p450 drug interaction table drug interactions. Examples of clinical inducers for p450 mediated metabolisms for concomitant use clinical ddi studies and or drug labeling 12 03 2019 strong inducers moderate inducers. Are either potent inhibitors or inducers of cyp450 enzymes.

Inhibitors inducers and substrates of cytochrome p450 isozymes remember inhibitors and substrates increase the effectiveness of another drug metabolized by that isozyme inducers decrease effectiveness.